Distance learning offers a unique opportunity to individualize and personalize instruction and establish inclusive learning environments for the range of diverse learners in every district, school, and virtual classroom. Applying high-leverage practices (HLPs) to lesson design and delivery, both in-person and virtually, empowers educators to provide the enabling conditions that ensure diverse learners are provided equitable access to high-quality instruction, across all grade levels and in all content areas. This special issues brief from the Collaboration for Effective Educator Development, Accountability, and Reform (CEEDAR Center) and the National Center for Systemic Improvement (NCSI) outlines how high-leverage practices (HLPs) can be employed to strengthen distance learning instruction for a diverse range of students by providing strategies to address common challenges students experience.